Incidence of Trisomy 8 and 9, Deletion of D13s319 and D20s108 Loci and Bcr/abl Translocation in Non-treated Essential Thrombocythemia Patients: an Analysis of Bone Marrow Cells Using Interphase Fluorescence in Situ Hybridization
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چکیده
percentage of blasts, M/E ratio, FAB subtype, but not cyclin E IR, were significantly associated with survival (Table 1). Multivariate analysis showed that IPSS (p=0.0068) and RAEB-t subtype (p=0.001) were independent predictors of survival. Interestingly, when the survival analysis was restricted to the low-risk subset of RA/RARS, the variables of age (p=0.0287), IPSS (p=0.0113) and FAB subtype (RA vs. RARS, p=0.0563) were associated with survival. At multivariate analysis, the variable of age (p=0.0284) was the only independent predictor of survival in RA/RARS. Although cyclin E IR was more prevalent in RA/RARS with an adverse clinical course, this trend did not achieve statistical significance, either at univariate (p=0.0759), or multivariate (p=0.0604) analysis, possibly because of the relatively small number of cases. Giancarlo Pruneri,* Nicola Fracchiolla,# Agostino Cortelezzi,# Maurilio Ponzoni,@ Patrick Maisonneuve,° Giorgio Lambertenghi-Deliliers# *Division of Pathology and Laboratory Medicine,°Epidemiology and Biostatistics, European Institute of Oncology, University of Milan, School of Medicine; #Division of Hematology, Ospedale Maggiore Policlinico, IRCCS, University of Milan, School of Medicine; @Division of Pathology, S. Raffaele H Scientific Institute, Milan, Italy
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تاریخ انتشار 2002